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pentobarbital will decrease the extent or impact of efavirenz by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.pentobarbital will lower the level or impact of darifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital will reduce the level or effect of amlodipine by a